Blowers are an awesome aesthetic on a hot rod.
How functional it is, and what you expect to attain can cover a wide range between being essentially "looks only" and 8 second quarter mile times.
Engine wise, like Spanky said, the bottom end and rotating assembly is where you start.
The bane of roots blowers is their miserable adiabatic efficiency, and the incumbent predisposition to detonation, hence the need to make wise cylinder head and piston choices, as well as accounting for what's available for gasoline in your area.
If you look at a lot of turbo or centrifugal blower setups, they at least have intercoolers to cool the boosted air, but unless you have a marine setup, or space for some extra hardware where you can run a Superchiller, you don't have that cooling with a roots blower.
That extra heat in the combustion chamber pretty much mandates forged pistons and aluminum heads if you want to use the blower for a real HP increase, as opposed to just looking cool.
There's some episodes of "engine Masters" on YouTube where they take a very basic crate engine, (cast pistons, rods, crank) and put a blower on it. The power gain is notable, and at least for a few dyno pulls, it doesn't blow up.
I'd hardly consider that evidence of it being a sound idea for your T.
Building a shortblock for a blower, or any power adder really, is significantly more costly than basic stock, so before you start gathering parts, be sure you plan the whole thing out in advance. . . Work out a budget, . . for a blower motor that makes good HP and will last, it's a major investment.
If you want an idea of the cost difference, just look at what it costs for an Edelbrock crate motor with carb, versus the same motor with a blower. . . . granted that's new retail pricing . . . but the difference is what's important.
As you look at blowers, about the biggest you can fit on a SBC and still have the original HEI distributor is a 6-71 . . you might squeeze an 8-71 with a small distributor.
If you're looking at a used blower setup, be sure to have a reputable shop, experienced with blower builds, check it out . . old and worn out is worse than none at all.
Best of luck on the build,
Darlene